Browsing by Subject "Molecular docking"
Now showing items 1-6 of 6
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A comprehensive in silico investigation into the pathogenic SNPs in RTEL1 gene and their biological consequences
(Brac University, 2023-03)Regulator of Telomere Helicase 1 (RTEL1) is a protein-coding gene that encodes an essential DNA helicase which is thought to be involved in preserving the telomere and genetic stability. Germline mutations in the RTEL1 ... -
A computational approach to find alternative drugs for managing depression
(Brac University, 2020-03)Depression is the most prominent disorder in the field of neuropsychiatry affecting more than 300 million people worldwide, according to Global Burden of Disease report, 2020. Frequent occurrences of depressive episodes ... -
Inhibition of Fibroblast Activation Protein alpha (FAP-α) in Colorectal Cancer
(Brac University, 2020-03)Being one of the leading cause of death worldwide, the fatality of colorectal cancer is increasing day by day causing approximately 862,000 deaths annually, according to IARC, 2020. As most of the conventional chemotherapeutics ... -
Molecular docking of Fluvastatin and Teneligliptin targeting AT1R in hypertension
(Brac University, 2019-05)Hypertension, or high blood pressure is a major risk factor causing cardiovascular diseases such as cerebrovascular stroke and ischemic heart disease. It is now considered as one of the most common disease and over 1.13 ... -
A novel vaccine designing approach through analyzing computational tools against pathogenic vibrio cholerae’s outer membrane protein of O1 strain as adjuvant
(Brac University, 2022-10)Cholera epidemic, history denotes it as “The Blue Death'', a deoxygenated, dehydrated death of humans due to the bacterial species named Vibrio Cholerae. When the sanitation system is extremely devastated by the purity ... -
Use of combination of satins as antagonists of SPARC in stomach cancer: an in silico study
(Brac University, 2019-05)SPARC is a protein found in gastric cell line. It has a dual role of tumor suppression and tumor progression. Over expression of SPARC in gastric cell line can lead to Stomach / Gastric cancer which is one of the leading ...